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As other xenobiotics, OTA undergoes biotransformation reactions catalyzed by phase I and II enzymes: more specifically, OTA is hydrolyzed by mammalian hydrolases and by gut microbiota in animals and in humans (Ringot et al

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Decreased tryptophan levels in the co-infected group might stem from HIV-induced malabsorption and Mtb -related kynurenine pathway activation, though not as pronounced as in the TB-only group

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