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4.2 Modulation of cellular signalling pathways 4.2.1 Interference with oncogenic pathways by lipid peroxidation (LPO) products Lipid peroxidation (LPO) products, which are reactive aldehydes like 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA), are formed as a result of oxidative stress in cells

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The 1.0mg dose produced the greatest efficacy but also the highest discontinuation rate due to adverse events (increased heart rate, hypertension, insomnia)

Research Summary Dihexa is a small peptide angiotensin IV derivative shown in preclinical studies primarily using rodent models to significantly enhance synaptogenesis, cognitive function, and neuroprotection by activating the HGF/c-Met pathway

Staff NP, Windebank AJ

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