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Two structural modifications distinguish this analog from the parent tridecapeptide: substitution of Met-4 with norleucine (Nle) and inversion of Phe-7 to the D-enantiomer, both of which are widely documented in the peptide chemistry literature as means of increasing conformational and oxidative stability of the reference standard

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152161, doi:10.1089/can.2018.0006

"S-acetyl-glutathione oral bioavailability." Int J Clin Nutr Diet

Further, the residue decomposition analysis revealed that the residue Trp108 exhibits the highest energy contribution in 4-NP binding followed by other crucial residues i.e., Phe95, Val95, Ile105, Tyr55 Phe356, Tyr359, and others as shown in Fig