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They are particularly useful for patients with medial or lateral compartment OA and can complement injection therapy by reducing the mechanical stress that drives ongoing cartilage breakdown

Dutasteride inhibits both type 1 and type 2 5-alpha reductase enzymes, making it a more potent DHT blocker than finasteride (which targets only type 2)

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Some research also suggests NAD+ plays a role in circadian rhythm regulation, providing another reason to favour morning dosing