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Mounjaro (tirzepatide): Manufactured by Eli Lilly and FDA-approved for type 2 diabetes, Mounjaro targets both GLP-1 and GIP receptors and has been widely prescribed off-label for weight loss

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* After adjustment for clinical factors, elevated FIB-4 was independently associated with: * Major adverse cardiovascular events (MACE) * Heart failure * All-cause mortality * Similar findings were observed using APRI, suggesting that the increased risk may be related to underlying fibrosis-associated pathophysiology rather than age alone