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R.LiottiF.PreveteN.et al (2010)

An early study 25 addressed this question by genotyping 9 SNPs associated with serum UA in a series of PD and matched control subjects to obtain a polygenic risk score (PRS) for low UA

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In addition, they cause the upregulation of genes coding for proinflammatory cytokines, thus contributing to the initiation of a vicious cycle that is self-feeding (47)