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REDEFINE 2, focused on type 2 diabetes, showed a mean 13.714.25% body weight reduction over 68 weeks with CagriSema compared to roughly 3% with placebo
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Crit Care Med 2016;44:4353 [DOI] [PubMed] [Google Scholar] 56.Masubuchi Y, Bourdi M, Reilly TP, Graf ML, George JW, Pohl LR.Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease
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These events drive aberrant protein aggregation, proteotoxic stress, mitochondrial dysfunction, and energetic collapse, culminating in cell death
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