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doi: 10.1016/j.biomaterials.2021.121326 101 HisadaRYoshidaNUmedaMBurbanoCBhargavaRScherlingerMet al

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However, DPP4i treatment was associated with worse outcomes (mortality results were not presented) in 27 patients with T2DM treated with DPP4is than in 49 treated with other glucose-lowering medications 87

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Potential risks include breast tenderness, headaches, slight increase in breast cancer risk with prolonged synthetic progestin use (not seen with micronized progesterone), blood clot risk with oral estrogen (not transdermal), and gallbladder disease risk with oral estrogen

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