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When an average heatmap of semaglutide-specific c-Fos increase (Figure 6B) was compared visually with the map of semaglutide VT750 brain access (Figure 2E), the largest overlap was in the hindbrain, mainly in the AP and NTS, indicating that the c-Fos response was a direct effect of semaglutide interaction with GLP-1R in these regions (Figure 6D)

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