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It modulates the monoaminergic system by augmenting serotonergic, dopaminergic, and noradrenergic neurotransmission, thereby facilitating mood regulation and cognitive functioning (66)

Amlodipine reacts with different cellular regulators, e.g., mitogen-activated protein kinases (MAPKs), transcription factors, and cell cycle proteins, which may affect the maintenance of pancreatic -cell function and insulin sensitivity and control the cellular reply to oxidative stress and abnormal protein synthesis induced by AGEs 95

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Vitamin B12 depletion, fat-soluble vitamin deficiency, and protein-losing enteropathy lead to anemia, coagulopathy, and hypoalbuminemia [36]

Antioxidants, oxidative damage and oxygen deprivation stress: a review

They are not off-label drugs