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[33] In contrast to peripheral administration, when administered intranasally via a nasal spray, oxytocin reliably crosses the bloodbrain barrier and exhibits psychoactive effects in humans

On the gastrointestinal front, literature has described mucosal barrier protection via modulation of endogenous prostaglandin (PGE2) and heat shock proteins (HSP70/90)

Rotating injection sites with each dose can help minimize irritation

Take these medications at least 1 hour before cagrilintide or 4 hours after to avoid absorption delays

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