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Cell Mol Life Sci 62(22):2531 Baker EN, Baker HM (2009) A structural framework for understanding the multifunctional character of lactoferrin

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In the presence of iron overload in vivo, hepatic hepcidin secretion is increased, binds to cell surface iron exporter protein FPN1, promotes FPN1 endocytic degradation, and reduces intracellular iron outward transport [31]