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Ionophores offers the opportunity of changing the internal ion which can facilitate different drug transport such as, magnesium or calcium ions

Shimizu et al., 1998)

Devadas S, Hinshaw JA, Zaritskaya L, Williams MS

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The sum of the data in relation to riluzole suggests that riluzoles main mechanism may not wholly depend on PKC downregulation, a known property of the drug, yet PKC downregulation may provide added benefit to other riluzole effects for an overall ultimate neuroprotective effect

Mercks medicinal-chemistry effort produced a series of peptidomimetics small molecules that mimic what those peptides do at the receptor while surviving oral administration