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The excess protein travels to the large intestine, where bacteria break it down

Parlevliet ET, Wang Y, Geerling JJ, Schroder-Van der Elst JP, Picha K, ONeil K, et al

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However, because the studies differed considerably in how they measured these behaviors and the types of participants they enrolled, the authors caution that the pooled estimate should be interpreted carefully

Fifty of the 173 users discontinued the agents before the 1-year study period was up, most often for gastrointestinal symptoms and "insurance issues." Limitations to the study included its single-center, retrospective design and small sample size