There are different types of stones, with some of the most common being calcium oxalate, calcium phosphate, and uric acid stones
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The combination targets different aspects of the problem
Third, translational gaps between preclinical models and clinical practice are prominent: most therapeutic candidates (e.g., natural products and repurposed drugs) have only been validated in rodent models, with limited data on human renal tissue responses, optimal dosing windows, or potential drugdrug interactions in clinical settings (e.g., in patients undergoing kidney transplantation or cardiovascular surgery)
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