And so if I'm treating someone 65 years old, 70 years old for obesity and obesity-related complications, I am concerned about how much weight they're going to lose, because part of it will be muscle and they're not going to be able to build it back likely
On the other hand, ablating the PVH or deleting GLP-1Rs in this brain region does not prevent the inhibitory effects on food intake and body weight of chronic systemic liraglutide [126, 130] or exendin-4 [128, 131]
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To prove the role of Gadd45a in the prefrontal cortex to influence the social behavior, we chose the region, mPFC, highly correlated with the processing of social information, to rescue the expression level of Gadd45a by stereotaxic injection of adenoviruses (AAV9-CAMKIIa-Gadd45a-EGFP) which could selectively overexpress Gadd45a in excitatory neurons (Fig
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