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Another possibility is that the rapid weight loss itself changes how the body builds and breaks down bone

These modifications render LC-MS/MS sequencing more complex due to altered hydrophobicity , ionization behavior , and fragmentation efficiency

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To this end, we utilized nhr-49(nr2041) mutants to investigate whether the loss of NHR-49 function would abrogate physiological and transcriptional changes observed with kin-19 RNAi