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It appears that the feeding center is chronically (tonically) active and that its activity may be transiently inhibited by activity of the satiety center occurring just after the ingestion of food

Hyperglucotoxicity and lipotoxicity Persistent hyperglycemia and excess fatty acids in the circulation due to overnutrition and IR have widespread and significant effects on cell function and mass

This is the percentage of calories that you want to go over or under what youd need to maintain your weight, depending on your goal

For everyone else, GLP-1 RAs are likely safe, and the risk of MTC is near nil

Curr Nanosci

Gomez-Sanchez et al., 2010