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2013 paper (PMID: 23055539) has an Expression of Concern issued by the journal in 2021, and the Benoist et al

One study with more than 300 participants saw a 15.8% decrease in body weight for semaglutide after 68 weeks.3 Another study saw a 12.4% decrease after 72 weeks.4 Averaging those two outcomes, someone weighing 200 pounds could reasonably expect to lose around 14% of their body weight after about 16 months

Fitzpatrick J, et al

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Users also report secondary effects such as reduced appetite and enhanced libido in some cases, often selected for those seeking steady pigmentation with mild metabolic side benefits

It demonstrates notable stability in human gastric juice and systemic activity across multiple administration routes