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Debut of diabetes was estimated as first-ever prescription for glucose-lowering drug, and diabetes duration at baseline was calculated as the time between diabetes debut until index date

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SCFAs activate G-protein-coupled receptors (GPRs) 41 and 43, also known as free fatty acid receptor 3 and free fatty acid receptor 2, on L-cells and engage intracellular signaling pathways

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During a VSG procedure, a large portion of the stomach is removed, reducing the amount of food a patient can consume and altering hunger hormones like ghrelin, which regulates appetite