For pernicious anemia, injections are needed every 2-3 months
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In most cases, these symptoms are mild to moderate and improve over time, but they can be severe enough for some patients to discontinue treatment (semaglutide STEP 1 trial results)
The 2025 IV pilot measured cardiac, hepatic, renal, thyroid, and glucose biomarkers and reported no abnormalities (Lee et al., 2025), which gives a sense of what those investigators considered worth checking
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Vitamin B12 also assists with the production of red blood cells and can help prevent anemia, which occurs when the blood does not have enough healthy red blood cells to transport sufficient oxygen throughout the body