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These cells strongly respond to the well-known hormone receptor drug agonists Semaglutide, Orforglipron, Tirzepatide, and Retatrutide (see figures)

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45 This therapeutic effect was associated with the normalization of autophagy-related markers (macroautophagy and chaperone-mediated autophagy) and reduced expression of pro-inflammatory mediators

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Helps regulate calcium absorption*

We then assessed the strength of these associations using Pearson correlation between the RSFC-derived PLS1 scores and the clinical PLS1 scores for each symptom domain