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It usually comes down to how the diagnosis is documented

Pinnell SR, Yang H, Omar M, Riviere NM, DeBuys HV, Walker LC et al (2001) Topical L-ascorbic acid: percutaneous absorption studies

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The most common complaint from people who finish a successful fat-loss protocol without a regenerative support compound is that their skin did not remodel as well as they expected at their target weight

10.3390/metabo10050181 88 LiH.JiaW

Each of those differences is a place where a mechanistically sound idea can fail