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However, NLY01, a brain-penetrant, pegylated, longer-lasting version of exenatide, provided no significant benefits in PD patients with a H&Y stage of 2.5 and an average disease duration of 1 year, as assessed by the MDS-UPDRS Parts II and III scores

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While simethicone does not specifically target hydrogen sulfide and has mixed evidence for efficacy, some patients find it provides modest relief

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