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Source: www.lilly.com In June 2024 , Novo Nordisk received regulatory approval in multiple markets for expanded indications of semaglutide, including cardiovascular risk reduction in patients with obesity, supported by clinical data showing a 20% decrease in major adverse cardiovascular events

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Furthermore, research was published explaining how human plasma DSIP decreases at the point of sleep regardless of the timing of the sleep, i.e, a persons usual sleep time, or a later sleep time, natural DSIP still decreased

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However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al