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Reduction of peripheral flow reserve impairs endothelial function in conduit arteries of patients with essential hypertension

Dosing begins at a low level to reduce gastrointestinal side effects and is gradually increased based on tolerance and therapeutic goals

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Unlike its predecessors, this compound activates three distinct receptor pathways: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon receptors

The FTO gene variant rs9939609, for example, is associated with metabolic changes that can elevate uric acid during rapid weight loss