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Your complete medical history should be reviewed, including: Cardiovascular conditions (hypertension, arrhythmias, heart disease) History of eating disorders or significant weight fluctuations Mental health conditions (anxiety, depression, bipolar disorder) Gastrointestinal disorders (gastroparesis, inflammatory bowel disease) Diabetes and current glucose-lowering medications Any history of substance misuse Gallbladder disease or pancreatitis Pregnancy and contraception must be discussed

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Burstein, M

Science 324 , 787790 (2009)

412 Notably, the DESTINY-Breast series of studies has demonstrated significant benefits for patients with brain metastases, leading to T-DXd replacing TDM-1 and TKIs as the standard second-line treatment for advanced HER2+ breast cancer

It is not approved for human use, veterinary use, therapeutic applications, diagnostic procedures, or clinical use