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Variations in the MTHFR gene can affect how the body metabolises B vitamins, including B12

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Local injection site reactions are the most frequently reported side effects

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

The kitchen fluorescent and the bedroom lamp can make the same vial look like two different colors

The pathophysiology of elevated vitamin B12 in clinical practice