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Topical application in women with photodamaged skin showed a significant reduction in lines and wrinkles as well as improved skin thickness compared to the placebo and Vitamin K cream after 12 weeks of application

Cancer Cell 36 , 582596 (2019)

But glucagon receptor activation appears to follow different rules than GLP-1 or GIP activation

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The overall effect of Trulicity 0.75mg Prefilled Insulin Pen's activation of the GLP-1 receptor is improved blood sugar control, especially in individuals with type 2 diabetes where there may be insufficient insulin production or decreased sensitivity to insulin

This is called pancytopenia (Zangemeister-Wittke 2009