Specific symptoms that should prompt medical consultation include an irresistible urge to move the legs, especially when accompanied by uncomfortable sensations such as crawling, pulling, tingling, or aching deep within the leg muscles
Individual factors such as metabolic rate, hormonal adaptation, and dietary habits can also reduce the medication's appetite-suppressing effect
And some people lose no weight, she notes
Patients taking concomitant medications that affect renal function, such as ACE inhibitors, ARBs, diuretics, or NSAIDs, require particularly vigilant oversight, as the combination may increase the risk of acute kidney injury during episodes of dehydration
While food does not significantly alter their absorption, this pre-meal timing optimises their effect on post-prandial glucose control
L.Q., C.L., T.Z., and B.D