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Tirzepatide activates both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, offering a dual mechanism that can enhance weight loss and glucose control beyond single-agent therapy

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Studies have shown that the expression of the thermogenic gene UCP1 is decreased in the BAT of GPER knockout (KO) mice [213]

These patients had to undergo repeated EGDs, contributing to significant time, cost, and resource burden [12]

Over 8 weeks, mean body weight in this cohort (50 adults) decreased from 73.69 7.73 kg at baseline to 67.36 7.87 kg at Week 8 (mean reduction: 6.33 kg

Commercializing CagriSema, if approved, could be challenging