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Local causes include mechanical, irritative or chemical trauma from drugs (e.g

One of these is PT-141 (Bremelanotide)

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Shekhonin, B

Dysbiosis in the gut microbiota promotes inflammation, insulin resistance and metabolic dysfunction through multiple pathways, including the production of short-chain fatty acids (SCFAs) and endotoxins such as lipopolysaccharides (LPS)

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