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& Yokota, H

There is no quality scientific evidence that suggests coffee enemas can treat chronic diseases

2012;7, article 68 doi: 10.1186/1750-1172-7-68

And critically, this is a molecule your own body manufactures, declines with age, and may benefit from being supplemented biologically, that is a coherent story rather than a marketing one

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Rapamycin exerts anti-ferroptotic effects by decreasing transferrin receptor expression, reducing cellular iron content, and activating the iron-regulated protein-1/2 (Irp1/2) system, potentially compensating for transferrin downregulation to maintain iron homeostasis (69)