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GLP-1 is a naturally occurring hormone that plays a critical role in regulating appetite: it signals your brains hypothalamus to promote feelings of fullness and reduce hunger

Patients with Renal Impairment A single-dose, open-label trial was conducted to evaluate the pharmacokinetics of saxagliptin (10 mg dose) in subjects with varying degrees of chronic renal impairment compared to subjects with normal renal function