Tong XY, Norenberg MD, Paidas MJ, Shamaladevi N, Salgueiro L, Jaszberenyi M, et al
Key numbers: +0.04 mmol/L in fasting glucose +0.060.08% in HbA1c +10% increase in diabetes risk with low/moderate-intensity statins +36% with high-intensity statins The effect is most evident in patients already at risk, with glucose values near the diagnostic threshold
The above studies suggest that GLP-1RAs may be a valuable strategy for the treatment of atherosclerosis (Figure 1) (Table 3)
Dual agonists may carry slightly higher rates of GI symptoms due to dual pathway activation, though individual tolerability varies
Cost and Accessibility 5-Amino-1MQ 5-Amino-1MQ costs $50-150 monthly from online research chemical suppliers
Therefore, determining what is a pathological dose of a specific LCAC will vary depending on the membrane distribution and integrity of the myocardial preparation, the experimental conditions, as well as the relative incorporation and/or cellular penetration of the superfused LCAC (Piper et al., 1984)
