In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect
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Properly shipped lyophilized peptide should arrive in a sealed vial with an intact flip-top cap, include an ice pack or insulated packaging for temperature control, have a clear label with batch number matching the COA, and show a white or off-white lyophilized cake or powder in the vial
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But the study didnt examine sublingual drops at all
