Vagal afferent neurons (VANs) expressing GLP-1Rs innervate intestinal mucosa and hepatic portal vasculature, suggesting these pathways may transduce peripheral GLP-1 RA effects to central satiety and glucoregulatory centers 57,58,59
In vitro studies demonstrate that cancer-associated fibroblasts (CAFs) support hormone-sensitive prostate cancer (HSPC) proliferation via glutamine and -KG secretion, fueling energy and biosynthetic demands (194, 195)
Further reading: How retatrutide works Retatrutide has shown greater average weight loss in trial data so far
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Pauza AG, Thakkar P, Tasic T, et al