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Menstruation itself, when both hormones drop to their lowest, is variable but often brings improved nausea

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Both routes show comparable efficacy in animals, though injections may act faster for localized issues

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Tolerability, cost, access, and individual response all matter

Dysregulation in any of these regulatory nodes may induce ultrastructural mitochondrial abnormalities and functional impairments, ultimately precipitating axonal degeneration and neuronal apoptosispathological hallmarks that define neurodegenerative pathogenesis (Hong et al., 2024)