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In MDD, this peripheral-central coupling is likely amplified by BBB dysfunction characterized by increased permeability, neurovascular inflammation, and associations with symptom severity [172, 173] thereby lowering the threshold at which peripheral KP activation translates into central glutamatergic, oxidative, and neuroimmune dysregulation

Beyond the reduction in energy intake, co-agonism seems to be able to affect food choice, favoring the consumption of healthy nutrients, how documented in experiments on mice and rats (67)

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However, those who do consume these products in their diets may not properly absorb the vitamin, such as the elderly, those who have had weight loss surgery, Crohns disease or celiac disease