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, and her team in Germany
10.1016/j.cca.2014.08.034 137
doi: Chavda VP, Ajabiya J, Teli D, Bojarska J, Apostolopoulos V
These limitations and mitigation strategies have been critically discussed in the section on glycolysis inhibition and were added to emphasize the translational challenges of 2-DG-based metabolic therapy
The new findings in recent years raise more questions about the actual function of GLP-1 and GLP1-RA on taste regulation, like the molecular mechanisms in which the decrease or hypersensitivity of some flavors results from receptor internalization, downregulation of ion channels (such as TRPM5), alterations in neurotransmitter release (ATP/5-HT) (162, 173) or either way for genetic variations and polymorphisms or if it is dependent on the density of specific subpopulations around TBC, since not all patients experience the same effect with medication (151, 158, 176)
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