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DOI : 10.1016/j.foodchem.2017.04.098

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The Xc- transport system which is composed of SLC3A2 and SLC7A11 proteins carries cystine into the cytoplasm where it is reduced to cysteine by thioredoxin reductases including thioredoxin reductase 1 (TXNRD1), thus participating in the synthesis of intracellular GSH, an essential cofactor for GPX4 activity

Reduced function of GPX4 is frequently observed in degenerative disorders

38 This can induce further recruitment of Th17 cells and neutrophils, producing a pathological vicious cycle