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JPEN J Parenter Enteral Nutr, DOI: 10.1177/0148607109353440 Rahbar, A
In intranasal delivery targeting the olfactory mucosa, overcoming the mucus barrier is the first challenge: drugs must dissolve in or traverse the mucus layer before encountering enzymatic degradation or mucociliary clearance (Rassu et al., 2018)
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Change history 10 April 2026 The original online version of this article was revised: Corresponding authors have been updated
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In the TRIUMPH-1 Phase 3 trial, participants on the highest dose of retatrutide lost an average of 28.3% of their body weight at 80 weeks
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