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Holst and colleagues in Denmark and by Joel Habener s group in the U.S., among others, who together elucidated the sequence and functions of GLP-1 in the mid-1980s ( [37] ) ( [38] )

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These effects are mainly triggered by the generation of reactive oxygen species (ROS) and encompass endothelial damage, platelet activation, smooth muscle cells, LDL oxidation, and the facilitation of interactions between endothelial cells and monocytes

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