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The mechanical properties of the microenvironment may be involved: a recent study revealed that tissue stiffness increases with age, impairing OPC proliferation and differentiation via the mechanoresponsive ion channel Piezzo1 (Segel et al., 2019)

Dosage timing is often set according to the study model (once daily, split doses, etc.)

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Memory, attention, and information processing all improve alongside anxiety reduction, suggesting the effects are not simply removing anxiety-induced impairment but actively enhancing underlying cognitive capacity