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Pivotal trials: what the NEJM data show Semaglutide STEP-1 (2021) and SELECT (2023) STEP-1 (Wilding et al., NEJM 2021) randomized 1,961 adults over 68 weeks on semaglutide 2.4 mg/week

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In vivo rodent models have investigated the central distribution and receptor occupancy of PT-141 following peripheral administration, examining whether the compound engages hypothalamic MC3R and MC4R populations

Weight change tends to follow gradually with proper titration and monitoring