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Rare but serious reactions include anaphylaxis and hypokalaemia during initial treatment

The risk is not only potency loss

The posts often share personal anecdotes, advice, and experiences about managing their dogs health, including specific incidents of medicating older dogs or dealing with new medication regimes

van der Burg J

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Nevertheless, despite the loss of 2A -adrenergic receptor expression, treatment with DA still causes smaller, though appreciable, dose-dependent inhibition of GSIS, and with higher potency