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As the therapeutic pipeline continues to expand from GLP-1 receptor agonists to engineered proteins and advanced drug-device combinations, the number of molecules that cannot tolerate traditional sterilization conditions is expected to grow

And they need to have IP or some kind of competitive moat

Discounts may limit the drug to a certain number of refills per year

The mechanisms of action of GLP-1R in DM and AD overlap, which suggests that GLP-1R may be a bridge between these two diseases

In healthy bone metabolism, bone resorption (the breakdown of old bone) and bone formation (the building of new bone) are coupled

In addition, in non-obese diabetic mice, DPP-IV inhibitors significantly increase Treg expansion and TGF- level