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This is known as the glutamine-glutamate cycle, which provides neurons with astrocyte-generated glutamate/y-aminobutyric acid (GABA)

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However, when the drug is taken in an overdose, the Uridine diphosphate-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in the human liver that participate in APAP detoxification become saturated, and a considerable proportion of this drug is activated by human CYPs (primarily CYP2E1)

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