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Patients on both medications may experience more pronounced early appetite suppression due to the combined effect, but this does not necessarily translate to faster weight loss if caloric intake drops too low, as severe restriction can slow metabolic rate

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(As an aside, at about 25 minutes into the podcast, Dr

Remove from heat and add in the rest of the ingredients

Mechanistically, hyperactivation of Drp1 suppresses hexokinase 1 (HK1), a glycolytic enzyme localized to the mitochondria, inducing metabolic reprogramming that promotes NLRP3-driven inflammation and oligodendrocyte pyroptosis (Pradeepkiran and Reddy, 2020