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Cheung EC, DeNicola GM, Nixon C et al (2020) Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer

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A recent narrative review found that while it can be effective, results are inconsistent and often require ongoing maintenance (PMC narrative review)

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Reasons patients give for stopping include reaching a plateau in weight loss, inability to tolerate side effects, or even inability to get the medication due to shortages

Short-lived enzymesubstrate interactions without stable complex formation are also in accordance with infinite k cat values and an inefficient competitive inhibition of ScGrx7